附件：文献综述溃疡性结肠炎动物模型选择的研究进展摘要：目的：溃疡性结肠炎(ulcerative colitis,UC )的确切病因与发病机理至今尚未阐明,给其治疗带来一定的困难,实验性UC动物模型的建立甚为必要。
方法：实验性UC可由免疫学方法诱导的UC模型（唑酮（Oxazolone,OXZ）诱导的 UC 模型、葡聚糖硫酸钠（Dextran sulfate sodium,DSS）诱导的UC 模型）和化学法诱导的UC模型（乙酸模型、过氧化亚硝酸钠（Na OONO2）诱导的 UC 模型、角叉菜胶刺激法诱导的 UC 模型、二硝基氯苯模型）刺激机体产生体液免疫反应而诱导。
结果：6种实验模型尽管制作原理、方法不同,但其病理特征方面与人类UC相似。
结论：6种模型可从不同角度探讨人类UC的病因、发病机理及治疗并提供方便、可行的研究手段。
本文就溃疡性结肠炎动物模型的一系列方法进行综述。
关键词 ：溃疡性结肠炎；动物模型；综述Abstract：Objective: the exact etiology and pathogenesis of ulcerative colitis (UC) have not been elucidated, which brings certain difficulties to its treatment. Therefore, itis necessary to establish an experimental UC animal model.Methods: experimental UC can be induced by immunological methods UC model (sanzuotong (Oxazolone, OXZ) induced UC model, Dextran sodium sulfate (Dextran sulfate sodium, DSS) induced UC model) and the UC model induced by chemical method (model of acetic acid, sodium nitrite peroxide (Na OONO2) induced UC models, the UC model induced by carrageen glue stimulation method, two nitrochlorobenzene model) to stimulate the body to produce induced humoral immune response.Results: although the principles and methods of the six experimental models were different, their pathological characteristics were similar to human UC.Conclusion: the six models can explore the etiology, pathogenesis and treatment of human UC from different angles and provide convenient and feasible research methods.This article reviews a series of methods in animal models of ulcerative colitis.Key Words: Ulcerative colitis; Animal models; review溃疡性结肠炎(ulcerative colitis,UC)是一种主要局限于大肠黏膜和黏膜下层的慢性非特异性炎症性疾病，呈反复性发作。
临床主要表现为腹痛、腹泻、脓血黏液便等消化系统的症状[1]。
研究发现， 该病发病率和患病率在我国有明显上升趋势。
但其确切病因和发病机制至今尚未阐明，治疗上也缺乏特异有效的药物。
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